Oxymorphone 10 mg Hydrochloride Oxymorphone 10 mg Hydrochloride is used to help relieve moderate to severe pain. It belongs to a class of drugs known as opioid (narcotic) analgesics. It works in the brain to change how your body feels and responds to pain. Classification Oxymorphone Brand : Opana, Opana ER Therapeutic: opioid analgesics Pharmacologic: opioid agonists Schedule II Pregnancy Category C What is Oxymorphone 10 mg Hydrochloride Oxymorphone is an old synthetic opioid, which has been available in the U.S. as an oral analgesic in both immediate- and extended-release formulations since 2006. This Fast Fact will review oral oxymorphone and its place in pain management. Distribution Formal studies on the distribution of oxymorphone in various tissues have not been conducted. Oxymorphone is not extensively bound to human plasma proteins; binding is in the range of 10% to 12%. Oxymorphone comes with several black box warnings that were in place before the company decided to stop selling it, and are common with many opioids. The drug was frequently abused because of the ability of people to crush, chew or dissolve the extended-release tablets.